Compounds > N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Page last updated: 2024-09-05

N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide and zd 6474

N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide has been researched along with zd 6474 in 1 studies

Compound Research Comparison

Studies
(N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide)		Trials
(N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide)		Recent Studies (post-2010)
(N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide)		Studies
(zd 6474)		Trials
(zd 6474)		Recent Studies (post-2010) (zd 6474)
90762388413

Protein Interaction Comparison

ProteinTaxonomyN-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide (IC50)zd 6474 (IC50)
Tyrosine-protein kinase ABL1Homo sapiens (human)0.1185
Epidermal growth factor receptorHomo sapiens (human)0.5373
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)1.6
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)0.7738
Platelet-derived growth factor receptor betaHomo sapiens (human)0.7885
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.343
Fibroblast growth factor receptor 1Homo sapiens (human)2.7925
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.0769
Vascular endothelial growth factor receptor 1 Homo sapiens (human)0.5812
Kinesin-1 heavy chainHomo sapiens (human)0.4
Vascular endothelial growth factor receptor 3Homo sapiens (human)0.1464
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.5425
Angiopoietin-1 receptorHomo sapiens (human)1.5335
Macrophage-stimulating protein receptorHomo sapiens (human)3.37
Coiled-coil domain-containing protein 6Homo sapiens (human)0.02
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.2

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1

Other Studies

1 other study(ies) available for N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide and zd 6474

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013